We are forming a team in the Harvard Medical School Department of Neurobiology dedicated to repurposing natural mechanisms of gene regulation to engineer precision viral vectors for gene therapy. First-generation gene therapy vectors lack optimal regulatory elements that lead to sub-therapeutic levels of expression and off-target toxicity. Our goal is to employ our in-house single-cell screening platform (PESCA, Hrvatin, et al., 2019), to sift through the mammalian genome and identify regulatory elements capable of driving optimal patterns of viral transgene expression to address a wide range of diseases. We are building a technology platform that fills a critical void in the gene therapy space. Our collective mission is to employ these regulatory elements to create novel viral vectors that unlock new indications and set a new standard in gene therapy. We have ambitions to spin off our work into a company to achieve this mission. We are recruiting a full-time senior scientist to join our team. This is an outstanding opportunity to play an integral role in developing the next-generation gene therapy platform. This position comes with broad responsibilities and an expectation that you will lead one or several key programs. Success will likely lead to the licensing of these programs into a new company, with potential future career opportunities. We are seeking highly motivated, collaborative, and effective individuals with strong scientific backgrounds capable of efficient experimental planning and management, who are excited by the prospect of pushing translational projects to completion in a fast-paced setting. Ideal candidates will have a strong background in molecular biology and next-generation sequencing assays.
This is a 12-month term appointment with the possibility of renewal contingent on funding.
Offer contingent upon successful completion of a pre-placement medical evaluation.
We are committed to cultivating an inclusive workplace culture of faculty, staff, and students with diverse backgrounds, styles, abilities, and motivations. We appreciate and leverage the capabilities, insights, and ideas of all individuals. Harvard Medical School Mission and Community Values
Harvard University offers an outstanding benefits package including:
Time Off: 3 - 4 weeks paid vacation, paid holiday break, 12 paid sick days, 12.5 paid holidays, and 3 paid personal days per year.
Medical/Dental/Vision: We offer a variety of excellent medical plans, dental & vision plans, all coverage begins as of your start date.
Retirement: University-funded retirement plan with full vesting after 3 years of service.
Tuition Assistance Program: Competitive tuition assistance program, incredibly affordable classes directly at the Harvard Extension School, and discounted options through participating Harvard grad schools.
Transportation: Harvard offers a 50% discounted MBTA pass as well as additional options to assist employees in their daily commute.
Wellness options: Harvard offers programs and classes at little or no cost, including stress management, massages, nutrition, meditation, and complementary health services.
Harvard access to athletic facilities, libraries, campus events, and many discounts throughout metro Boston.
The Harvard Medical School is not able to provide visa sponsorship for this position.
Master's Degree required. A Ph.D. in biological sciences or related field may count towards experience.
4+ years of hands-on molecular biology - interested individuals should be capable of performing all steps of the platform pipeline. Experience in standard molecular biology techniques, including high-throughput plasmid design and cloning, PCR, RNA/DNA extraction and validation, qPCR. Strong organizational and documentation skills. Good interpersonal and collaborative skills, maintaining a friendly but professional working environment while contributing positively to development and troubleshooting. Strong written and oral scientific communication skills to keep leadership informed and to interface with academic and industry collaborators. Ability to adapt to and effectively manage changes in a fast-paced and dynamic environment.
EQUAL OPPORTUNITY EMPLOYER: We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, or any other characteristic protected by law.
The Edmond J. Safra Center for Ethics at Harvard University seeks to strengthen teaching and research about pressing ethical issues; to foster sound norms of ethical reasoning and civic discussion; and to share the work of our community in the public interest.
Widespread ethical lapses of leaders in government, business and other professions prompt demands for more and better moral education. More fundamentally, the increasing complexity of public life - the scale and range of problems and the variety of knowledge required to deal with them - make ethical issues more difficult, even for men and women of good moral character. Not only are the ethical issues we face more complex, but the people we face them with are more diverse, increasing the frequency and intensity of our ethical disagreements.
Given these changes in the United States and in societies around the globe, the Center seeks to help meet the growing need for teachers, scholars, and leaders who address questions of moral choice across many of the professions and in public life more generally, and promotes a perspective on ethics informed by both theory and practice. We explore the connection between the problems t...hat professionals confront and the social and political structures in which they act. More generally, we address the ethical issues that all citizens face as they make the choices that profoundly affect the present and future of their societies in our increasingly interdependent world.