There is an exciting new opportunity at the University of Southern California for highly motivated Postdoctoral candidate committed to developing a successful career in chromatin biology or stem cell biology. Our lab has extensive expertise and excellent track record in studying epigenetic regulations of cell fate determination using embryonic stem cell, or cancer cell as the model. We employ multidisciplinary approaches to understand the functions of histone modifying enzymes e.g. MLL and MOF, in a variety of physiological and pathological processes.Â
Responsibilities include a) Developing novel approaches to characterize epigenomes in stem cells and cancer cells, b) Conducting cellular, molecular and in vivo experiments for hypothesis-driven research, and c) Preparing presentations and publishing scientific manuscripts under the direction of the Principal Investigator. Candidate will enjoy a highly collaborative environment in Dou lab as well as USC research community. It is essential that the applicant has excellent organizational and communication skills. The postdoctoral trainees will be encouraged to submit their own fellowship and grant applications during their periods of training.Â
Interested candidates should send a CV to Dr. Dou (email@example.com), Professor of Medicine and Co-leader of the Genomic and Epigenomic Regulation Program in the USC/Norris Comprehensive Cancer Center.
Representative publications (2018-2021):
Histone acetyltransferase MOF regulates quiescence in ground-state pluripotency through fatty acid oxidation. Cell Stem Cell, 27(3):441-458, 2020.
Cryo-EM structure of the human Mixed Lineage Leukemia-1 complex bound to the nucleosome. Nature Communication, 10(1):5540. doi: 10.1038/s41467-019-13550-2, 2019.
Facile target validation in an animal model using monobodies. Nature Chemical Biology, 14(9), 895-900, 2018.
HOXA9 reprograms the enhancer landscape during leukemic transformation. Cancer Cell, 34, 643-658, 2018.
Preferred Education:PhDin Molecular and Cellular Biology, Genetics, Developmental Biology, or in a relevant field
Preferred Experience:Experience with standard molecular and cellular biology techniques and familiarity with genomic technologies are essential. Experience in performing epigenomic assays (CRISPR/Cas9, ChIP, ATAC-, 4C-seq) will be a plus but not required. The ability to learn new techniques quickly and a strict attention to details of experimental protocols are required.
Preferred Field of Expertise:Leukemia, embryonic stem cells, cancer epigenetics
Percentage of Time:100%
Fixed Term: 04/01/2021-06/30/2022
Minimum Education: Ph.D. or equivalent doctorate within previous five yearsMinimum Experience: 0-1 yearMinimum Field of Expertise: Directly related education in research specialization with advanced knowledge of equipment, procedures and analysis methods. Strong background in computer programming, mathematical modeling is required.
USC is the leading private research university in Los Angeles—a global center for arts, technology and international business. With more than 47,500 students, we are located primarily in Los Angeles but also in various US and global satellite locations. As the largest private employer in Los Angeles, responsible for $8 billion annually in economic activity in the region, we offer the opportunity to work in a dynamic and diverse environment, in careers that span a broad spectrum of talents and skills across a variety of academic and professional schools and administrative units. As a USC employee and member of the Trojan Family—the faculty, staff, students, and alumni who make USC a great place to work—you will enjoy excellent benefits, including a variety of well-being programs designed to help individuals achieve work-life balance.