Dr. Helen Goodridge is looking for a Research Associate II to join her research group in the Cedars-Sinai Regenerative Medicine Institute!
The Goodridge Lab studies the production of myeloid cells (neutrophils, monocytes, macrophages and DCs) and their roles in infectious and inflammatory diseases, cancer, aging and tissue regeneration, working closely with other Cedars-Sinai researchers (including the Svendsen, Chen and Hazelett groups), as well as external collaborators. In recent studies, the Goodridge Lab has defined novel pathways and mechanisms of monocyte differentiation (PMID: 25597637, 29166589), demonstrated the impact of hematopoietic aging/rejuvenation on cognitive function (PMID: 30820468), and defined immune dysregulation in severely ill COVID-19 patients (PMID: 33357411). The lab's ongoing research projects involve analysis of human cells, mouse and human cell culture, cellular and molecular biology assays, and mouse models. The Research Associate II will provide technical support related to the preparation and analysis of laboratory specimens and conduct laboratory research under the direction of the PI or research staff. To learn more, please visit: Goodridge Research Lab | Cedars-Sinai (cedars-sinai.edu)
The RAII's principal duties will include tissue culture, animal husbandry, microscopy, data analysis, record keeping, ordering reagents and maintaining equipment. The RAII will be expected to work efficiently on their own and cooperatively with a team of faculty, postdocs, students and other research associates. Participation in laboratory meetings, maintaining laboratory notebooks, performing calculations, organizing and analyzing data, summarizing methods and results of experiments, and preparing data for publication will be required. Duties will include but are not limited to: project-based bench duties (cell culture, cell and molecular biology techniques, microscopy etc.), animal husbandry, ordering supplies and maintain inventories, preparing chemical solutions and culture media, maintaining general lab organization and cleanliness.
Primary Job Duties and Responsibilities:
Assist in the design of new complex or unusual protocols and techniques.
Keeps accurate and detailed records of experiments and results and assists in identifying and troubleshooting of unexpected results
Orders laboratory supplies and supports laboratory operations
Maintains lab equipment and related records and may coordinate use of lab equipment.
Assist in the operation of specialized equipment, as required by the area of research
Orients research laboratory assistants or lower level research associates and undergraduate student researchers on day-to-day lab operations and routine procedures.
Minimum of a Bachelor of Science or Bachelor of Arts degree in biological science, required.
Experience and Skillset:
Two (2) years of laboratory experience, required.
Interested in immunology and/or hematology.
Prior experience of flow cytometry, tissue culture, molecular biology, rodent studies and/or evaluation of human samples is desirable.
Bioinformatics/computational experience (e.g. scRNA-seq analysis) would be a significant advantage.
Understanding of general research objectives.
Knowledge of routine laboratory procedures, experimental protocols, and overall lab organization.
Applicant must be highly motivated and work independently.
Must have superior interpersonal, communication and organization skills and the ability to work across company disciplines and functional units, and computer application experience.
Must possess computer skills to include, but not limited to, Excel, PowerPoint, and Word.
Ability to simultaneously manage multiple clerical trials, and attention to details.
Experience with cell culture required; experience with stem cell culture preferred.
Animal husbandry experience, preferred.
Knowledge of with molecular biology, microscopy, immunohistochemistry and Western blotting preferred.
Willing to perform animal husbandry and work with mouse and human tissue.
Scheduling flexibility including evening, weekend and holiday rotation commitment, if necessary.
Working Title: Research Associate II - Goodridge Lab
Providing healthcare for more than 100 years, Cedars-Sinai has evolved into one of the most dynamic and highly renowned medical centers in the world. Along with caring for patients, Cedars-Sinai is a hub for biomedical research and a training center for future physicians and other healthcare professionals. This attracts exceptional talent to Cedars-Sinai, including world-renowned physician-scientists who seek a place where they can both conduct research and see patients--the ideal formula for discovery and its translation into cures. Our patients benefit from access to doctors at the top of their fields, and our researchers have an ideal community in which to study the impact of healthcare challenges, and reflect that knowledge in their research. The greater Los Angeles area in which Cedars-Sinai resides possesses unparalleled cultural and ethnic diversity which offers outstanding opportunities for translational and clinical research and a dynamic environment for medical education.Although community based, Cedars-Sinai is a major t...eaching hospital affiliated with the David Geffen School of Medicine at the University of California, Los Angeles (UCLA). Cedars-Sinai has highly competitive graduate medical education programs in more than 50 specialty and subspecialty areas, a graduate program in biomedical sciences and translational medicine, a clinical scholars program directed towards junior physicians with aspirations to become clinical scientists, and post graduate training opportunities.There are more than 250 full-time faculty members at Cedars-Sinai. The voluntary medical staff, comprised of more than 2,200 specialty board-certified or board-qualified physicians, represent all of the specialties and subspecialties and collaborate with full-time medical staff in the teaching responsibilities of the graduate medical education programs.