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Application Review Date
The First Review Date for this job is: April 16, 2021
The He Lab studies the functional importance of the non-coding genome in development and disease.
It is increasingly clear that the vast non-coding genome encodes important genetic information that regulates development and disease. The overall focus of the He lab is to understand the biological functions and the molecular regulation of various non-coding transcripts, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and retrotransposons. Using mouse and frog genetics, genomics, cell and molecular biology, we aim to dissect the functional interplay between protein-coding genes and non-coding genes in development and disease. In particular, we will dissect the molecular mechanisms that define the totipotent stem cell cell fate in preimplantation embryos, and will elucidate the cellular and molecular events that promote cancer metastasis.
Developing and Designing experiments characterizing ncRNA function in development and disease.
Conducting experiments, including but not limited to:
Derivation of mouse ESCs/generation of mouse iPSCs in the miRNA-deficient background
Characterize the pluripotentcy of ESCs/iPSCs in vitro by real-time PCR and immunostaining
Determine the differentiation potential of ESCs/iPSCs in vitro and in vivo by embryoid body (EB) differentiation and teratoma analyses
Manipulation of the expression of miRNAs and/or their targets by overexpression or shRNAs
Analyze expression profiles and epigenetic states of ESCs/iPSCs by high-throughput sequencing (RNA-seq and ChIP-seq).
Mouse organization, including mating and manipulating pre-implantation embryos.
Lab Management and Supervision:
Responsible for purchasing lab equipment, supplies, safety, and coordinating travel arrangements and reimbursements.
Responsible for planning and supervising the work of the undergraduate and graduate lab assistants.
Will collaboratively design and contribute to research projects with graduate students, postdoctoral scholars, and the PI.
Responsible for training staff and students on lab equipment and new techniques.
Other duties as assigned.
Experience in basic molecular biology, mouse genetics or cell biology.
Experience designing and analyzing experiments
Experience with cell culture, including primary cells and stem cells
Experience with mouse management, mouse genetics
Demonstrated strong interpersonal and communication skills, and writing skills.
Bachelor's degree or equivalent degree in Molecular and Cell Biology or a related field.
Experience with high-throughput sequencing, including RNA-seq or ChIP-seq.
Experiences with simple bioinformatics analyses.
Salary & Benefits
This is a monthly paid (exempt) position. Annual salary will be commensurate with experience (stepped rates).
For information on the comprehensive benefits package offered by the University visit:
The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or protected veteran status. For more information about your rights as an applicant see:
The University of California was chartered in 1868 and its flagship campus - envisioned as a "City of Learning" - was established at Berkeley, on San Francisco Bay. Today the world's premier public university and a wellspring of innovation, UC Berkeley occupies a 1,232 acre campus with a sylvan 178-acre central core. From this home its academic community makes key contributions to the economic and social well-being of the Bay Area, California, and the nation.