This position is for a Laboratory Manager for the Tumor Immunogenomics Lab (TIL) initiative that will be a collaborative research program between Dr. Vincent, Dr. Alexander Rubinsteyn (Assisant Professor of Genetics, Computational Medicine Program), and Dr. Jared Weiss (Associate Professor of Medicine, Division of Medical Oncology). TIL will integrate the wet lab research portfolios of Drs. Vincent, Rubinsteyn, and Weiss in the areas of antigen identification and targeting via novel therapeutics, including work being done in therapeutic neoantigen vaccination and epitope-optimized SARS-CoV-2 vaccination. The person filling this role will need to manage multiple discrete projects (including inventory, purchasing, and budgeting) and supervise and train multiple lab-based personnel concurrently. Project management work will include designing, executing, troubleshooting, and supervising experiments, informed by the scientific literature and with input and direction from the principal investigator. This will require a high degree of scientific independence. This person will also need to prepare formal scientific communications including reports, presentations, manuscripts, and figures/text for funding proposals.
This specific laboratory work associated with this position includes characterization of the circulating and tumor-infiltrating lymphocyte populations in human tumors and associated murine models. This work also includes analyses of the genetic diversity of T cell receptor (TCR) repertoires and gene-expression profiling using next-generation sequencing and single-cell sorting and sequencing techniques in the same models. Further, this work involves characterization of the immune response to immunotherapies in multiple clinical trials and using this knowledge to translate understanding into preclinical experiments to test novel therapeutic strategies. Experiments will be done in multiple tumor types. This position will require the person filling it to be a part of a multidisciplinary team with regular contact with practicing medical oncologists and scientists from other disciplines within the cancer center. Finally, the person filling this position should have a high degree of capacity to work independently as well as collaboratively as part of a multidisciplinary team, including well-developed skills in project management, supervision of experimentalists, and training of lab members in relevant assay techniques.
Education and Experience:
Bachelor’s degree in a discipline related to the area of assignment; or equivalent combination of training and experience. All degrees must be received from appropriately accredited institutions.
The applicant must have deep expertise in flow cytometry, ELISA, and processing biological samples for therapeutic and diagnostic procedures. The applicant must have experience in scientific project management, including expertise in process development, process management, budgeting, and reporting.
Degree in Biology, Biochemistry, Biophysics, Bioinformatics/Computational Biology, Chemistry, Clinical Laboratory Science, Genetics, Immunology, Medical Technology, Microbiology, Molecular Biology, Physiology, Pharmacology, or Zoology. Experience with project management and sample tracking with LIMS, mLIMS and/or similar systems.
The University of North Carolina at Chapel Hill is an equal opportunity and affirmative action employer. All qualified applicants will receive consideration for employment without regard to age, color, disability, gender, gender expression, gender identity, genetic information, race, national origin, religion, sex, sexual orientation, or status as a protected veteran.
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