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The Department of Genome Sciences is part of the University of Washington School of Medicine and is comprised of 30 labs addressing leading edge questions in biology and medicine by developing and applying genetic, genomic and computational approaches taking advantage of genomic information now available for a host of species. GS is making major contributions in the application of genome science to understand the fundamentals of biology and to improve human health and wellbeing. Genome Sciences is a collaborative department supported by very different academic disciplines. We work with a multitude of Program Investigators (PIs) in departments both on the UW campus as well as worldwide. The department has gone through significant expansion since its beginning in 2001 with annual grant awards of $57M in FY20.
The Northwest Genomics Center (NWGC) at the University of Washington is one of the leading genome centers in the United States. The NWGC, housed in the Department of Genome Sciences, is the largest self-sustaining genome center in the Pacific Northwest and one of the most successful genome centers in the country. It has partnered to deliver exome and/or whole genome sequence (WGS) data for many highly successful large-scale human genetic projects for both rare conditions and common diseases. These projects include the Centers for Mendelian Genomics (CMG), the NHLBI Trans-Omics for Precision Medicine Program (TOPMed) and, most recently, the All of Us Research Program.
The Department of Genome Sciences’ Northwest Genomics Center currently has an outstanding opportunity for a Research Scientist/Engineer 2 – Library Construction.
POSITION PURPOSE The Research Scientist will conduct laboratory research focusing on the identification of DNA variation in human populations in a high-throughput genomics laboratory in the Department of Genome Sciences. The primary focus is to produce high quality sequencing libraries in a team setting. This position will requires expertise in molecular biology and genomics protocols and the ability to perform research and take responsibility for assuring quality, cost effectiveness and timeliness for large projects.
The Research Scientist will work under immediate supervision to meet project deadlines and complete assigned tasks by implementing well-established protocols and evaluating and developing new protocols. Weekly meetings are held to discuss project status.
Dimensions and Impact to the University This position will work in a prominent laboratory whose work impacts other researchers worldwide. High functionality will be reflected in even greater funding opportunities and enhancement of the reputation of the University as a biomedical research powerhouse.
Carry out laboratory protocols for next-generation DNA and RNA library preparations.
Perform standard molecular biology protocols and assist in the development of new methods for DNA, RNA, and methylation analysis.
Develop and maintain precise laboratory protocols and records.
Work within a laboratory team environment to process and track DNA and RNA samples.
Program and operate robotics stations for sample preparation.
Implement quality-assurance protocols.
Perform routine assessment of data quality. Assist with trouble-shooting and daily quality control of data.
Aid in the development of new experimental methods and assist laboratory co-workers and/or the PI in meeting long-term scientific goals.
Attend Genome Sciences and University meetings, retreats, status updates, orientations and planning days when necessary.
Other duties may be assigned.
Bachelor’s degree in Biology, Genetics/Biochemistry, Chemical or Biomedical Engineering, or other related Life Sciences field and 2 years laboratory experience using standard molecular biology techniques, either in a professional or academic setting
Equivalent education/experience will substitute for all minimum qualifications except where there are legal requirements such as license/certification/registration.
Working knowledge of molecular biology, genetics, and/or chemistry
Experience in DNA and RNA library sequencing and construction
Working knowledge of molecular biology, genetics and/or chemistry
Excellent technical skills at the bench
Excellent recording keeping and ability to refine and develop protocols
Strong analytical and problem solving skills
Excellent written, verbal and interpersonal communication skills
Must be highly organized with a strong attention to detail
Open to receiving direction and to asking for assistance when needed
Ability to work both independently and collaboratively
Experience in a high-throughput genomics laboratory specializing in next-generation sequencing
Experience with liquid handling systems, specifically, Janus, Zepher, and Sciclones systems, including program development
Experience working with next-generation sequencing technologies (various Illumina platforms)
Experience working in a CLIA-certified environment
Standard CLIA Lab Environment
Application Process: The application process for UW positions may include completion of a variety of online assessments to obtain additional information that will be used in the evaluation process. These assessments may include Work Authorization, Cover Letter and/or others. Any assessments that you need to complete will appear on your screen as soon as you select “Apply to this position”. Once you begin an assessment, it must be completed at that time; if you do not complete the assessment you will be prompted to do so the next time you access your “My Jobs” page. If you select to take it later, it will appear on your "My Jobs" page to take when you are ready. Please note that your application will not be reviewed, and you will not be considered for this position until all required assessments have been completed.
Founded in 1861, the University of Washington is one of the oldest public institutions in the west coast and one of the preeminent research universities in the world. The University of Washington is a multi-campus university comprised of three different campuses: Seattle, Tacoma, and Bothell. The Seattle campus is made up of sixteen schools and colleges that serve students ranging from an undergraduate level to a doctoral level. The university is home to world-class libraries, arts, music, drama, and sports, as well as the highest quality medical care in Washington State and a world-class academic medical center. The teaching and research of the University’s many professional schools provide undergraduate and graduate students the education necessary toward achieving an excellence that will serve the state, the region, and the nation. As part of a large and diverse community, the University of Washington serves more students than any other institution in the Northwest.