| Department: MED-Neurology
Salary/Grade: NEX/15 Job Summary: The Carvill Lab in the Department of Neurology is seeking a new research technologist to join our team. Our research focuses on the genetic and epigenetic basis of epilepsy; we use numerous genomic technologies as well as iPSCs to study pathogenic mechanisms towards discovering new precision therapies. We are seeking a technician to work on multiple NIH and Foundation-funded research projects, as well as to oversee the general day to day running of the lab. Learn more about our work and the team here: https://sites.northwestern.edu/carvilllab/ Conducts complex experimental research in a research lab, functioning as a specialist or technical expert. Manages one or more phase(s) of a major project(s) or all activities of a small project. Ensures overall lab compliance with all associated rules & regulations. Specific Responsibilities: - Acting as a technical expert or specialist in a particular field within a research lab, establishes & optimizes protocols & coordinates conduct of multiple complex experiments.
- Reviews results & revises protocols as necessary to ensure that project objectives are attained.
- An expert level in many of the stated skills is required.
Molecular Biology: - DNA, RNA, Protein isolation, purification and expression
- Analysis, Western blotting
- PCR, RT-PCR
- Plasmid preparation
- Cloning, mapping and sequencing of DNA
- Recombinant virus production and purification
Cellular Biology: - Cell culture, cell isolation
- Functional studies
- Transfection
Histology: Immunology: Animal: - Husbandry
- Database management of colony
Administration - Oversees & manages lab databases which may include ensuring that experiments are observed & that data is collected & entered correctly.
- Reviews & analyzes data.
- Creates computer models, graphs, reports & summaries for use in publications, professional journals, & grant applications.
- Co-authors scientific papers for presentation & publication.
- Researches & obtains funding.
- Creates & maintains lab manuals regarding operating, safety, etc. procedures.
Finance - Creates lab financial plan & budget/audit expenses.
- Obtains sales quotes for lab equipment & supplies.
- Reviews & adjusts expenses to decrease costs.
- Oversees repair & maintenance of all lab equipment.
- Ensures that lab supplies are ready & available when necessary.
Supervision - Trains, directs, assigns duties to & may supervise lab EEs, students, residents &/or fellows.
Miscellaneous - Performs other duties as assigned.
Minimum Qualifications: - Successful completion of a full 4-year course of study in an accredited college or university leading to a bachelor's or higher degree in a scientific major or related; OR appropriate combination of education and experience and 5 years' lab/bench or other relevant experience required; OR
- Successful completion of a full course of study in an accredited college or university leading to a master's or higher degree in a scientific major or related; OR appropriate combination of education and experience and 3 years' lab/bench or other relevant experience.
Minimum Competencies: (Skills, knowledge, and abilities.) - Working knowledge of computers and software (Microsoft Word, Excel) basic statistics; ability to work independently, Strong organizational skills and multitasking
Preferred Qualifications: - Bachelor’s or Master’s degree in the life sciences
- Previous experience working in a research lab (minimum 5 years) is essential
Preferred Competencies: (Skills, knowledge, and abilities) - Experience with iPSC maintenance and differentiation, preferably to a neuronal lineage.
- Genome editing with CRISPR/Cas9
- Expertise in next generation sequence technologies and basic understanding of analysis, for instance: targeted/exome/genome sequencing, RNA-seq, ChIP-seq, ATAC-seq, scRNAseq or similar
- Track record of training junior scientists, primarily undergraduates and graduate students.
Northwestern University is an Equal Opportunity, Affirmative Action Employer of all protected classes, including veterans and individuals with disabilities. Women, racial and ethnic minorities, individuals with disabilities, and veterans are encouraged to apply. Hiring is contingent upon eligibility to work in the United States.
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