Washington University is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, genetic information, disability, or protected veteran status.
This position is full-time and works approximately 40 hours per week.
Department Name/Job Location:
This position is in the Department of Internal Medicine, Division of Oncology - Bone Marrow Transplant. This position is for the Medical School Campus.
The Challen Lab is seeking a senior scientist to collaborate with the Principal Investigator on the design, conduct and reporting of research projects relating to the genetic and epigenetic regulation of hematopoietic stem cell (HSC) function, and the clonal evolution of blood cancers. The overall goal of the lab is to understand how epigenetic modifications interface with genetic mutations to drive the progression of pre-malignant HSCs into fulminant blood diseases such as MPN, MDS and AML. We are interested in understanding how these processes corrupt normal HSC function and facilitate the clonal expansion of pre-malignant HSCs as a precursor to blood cancer. The translational potential of this work is to develop specific interventions to target these early clones as a mechanism of blood cancer prevention. The successful candidate will have experience in mouse models, flow cytometry, molecular techniques and basic computational analysis.
For more information, please visit the lab website and Twitter –
In collaboration with the PI, will design, execute, analyze and present data on scientific projects. Will be the intellectual leader of several independent studies.
Assists with grant preparation and reporting.
Prepares and submits papers on research.
Complies with established safety procedures and maintaining required documentation on laboratory and specimen conditions.
Manages research project with other institutions and investigators.
Ph.D., M.D. or an equivalent terminal degree and at least three years of postdoctoral experience.
High-level analytical reasoning and problem-solving skills.
Demonstrated working knowledge of standard and advanced laboratory procedures and equipment relating to the research goals. This includes, but is not limited to, flow cytometry, western blotting, cell culture, and molecular biology.
Ability to communicate in oral and written form with all levels of personnel and technical publications.
Ability to work well independently and as a team member.
The hiring range for this position is $53,830 - $72,675 annually.
All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. Current employees applying for a new position within the university may be subject to this requirement. The screenings will include a criminal background check and, as applicable for the position, other background checks, drug screen, employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening.
Please attach a copy of your most current signed performance evaluation (completed within the last 18 months) to your online account. If you have not received a performance evaluation, you may provide two current signed letters of recommendation (written within the last 18 months), preferably to include one letter from either a current or recent former supervisor. To attach these documents, go to: My Career Tools, Add Attachment, Attachment Type – Performance Reviews or Letters of Recommendation.
Washington University in St. Louis, a medium-sized, independent university, is dedicated to challenging its faculty and students alike to seek new knowledge and greater understanding of an ever-changing, multicultural world. The University offers more than 90 programs and almost 1,500 courses leading to bachelor's, master's and doctoral degrees in a broad spectrum of traditional and interdisciplinary fields, with additional opportunities for minor concentrations and individualized programs. The faculty is composed of scholars, scientists, artists and members of the learned professions. They serve society by teaching; by adding to the store of human art, creativity, understanding, and wisdom; and by providing direct services, such as health care.