A postdoctoral position is available in the Hanson Lab in the Herman B Wells Center for Pediatric Research at the Indiana University School of Medicine. Our lab is interested in the regulation of the innate and adaptive immune response pathways and how these are impacted by genetic mutations we identify in patients with one of the rare Autoinflammatory Diseases. In particular, we are interested in studying activation and regulation of NF-kB, type I IFN and the various inflammasomes.
The candidate will perform advanced molecular and biochemical studies to identify genetic mutation and determine the mechanisms and downstream effects of altered gene function. The candidate will use in vivo and in vitro models in genetically modified mice, primary patient samples, pluripotent stem cells, and engineered cancer cell lines.
Duties and responsibilities include performing in vivo characterization of mouse models of disease and mouse and human cell culture experiments; extensive use of cell and molecular biology techniques and includes small animal (mouse) handling and dosing. Mouse handling techniques include peritoneal and tail vein injection of mice, performing cheek bleeds, dissection and cell harvest, primary and cancer cell culture, DNA transfection, qPCR, immunoblot, flow cytometry and immunofluorescence. Experience with handling limited human samples and mice is desirable. Having experience with or interest in developing basic computational analysis skills, such as processing data in R, is also is desirable.
As the nation's largest medical school, IUSM is committed to being an institution that not only reflects the diversity of the learners we teach and the patient populations we serve, but also pursues the values of diversity, equity and inclusion that inform academic excellence. We desire candidates who enhance our representational diversity, as well as those whose work contributes to equitable and inclusive learning and working environments for our students, staff, and faculty. IUSM strives to take an anti-racist stance, regularly evaluating and updating its policies, procedures, and practices to confer equitable opportunities for contribution and advancement for all members of our community. We invite individuals who will join us in our mission to advance racial equity to transform health and wellbeing for all throughout the state of Indiana.
PhD in Biochemistry, Molecular or Cell Biology, Immunology, or a related field and/or MD. The candidate should be able to work closely with others in a team setting as well as independently. The candidate will be trained to design and conduct experiments, and must have effective oral and written communication skills.
Department Contact for Questions:
Dr. Eric Hanson, M.D. Associate Professor in Pediatrics, Microbiology and Immunology, and Medical and Molecular Genetics Division Chief, Pediatric Rheumatology at firstname.lastname@example.org
OAA #: IUSM009952016
Internal Number: 10399
About Indiana University Purdue University Indianpolis - IUPUI
Founded in 1820, Indiana University is the state’s public university system, comprised of two core campuses—IU-Bloomington and IUPUI—and six regional campuses located throughout the state. Combined, the total student population is more than 114,000 undergraduate, graduate and professional school students. IU is one of the largest employers in the state, with over 20,000 faculty and staff. Indiana University is an equal employment and affirmative action employer and a provider of ADA services. Diversity and inclusion remains a core commitment to IU’s mission to cultivate an educational environment that supports equal access, participation and representation on all of its campuses and that provides educational and career opportunities for all.