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Post-Doctoral Research Fellow - Functional Genomics and RNA Biology
Fred Hutchinson Cancer Research Center
Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutchs pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nations first cancer prevention research program, as well as the clinical coordinating center of the Womens Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here. The Subramaniam lab is part of the Basic Sciences Division and the Computational Biology Program at Fred Hutch in Seattle. Members of the lab come from a variety of scientific backgrounds including physics, biochemistry, and microbiology. The lab places a strong emphasis on one-on-one mentoring and on providing a supportive environment for learning and research. Trainees are prepared for a wide range of careers in academia and industry through learning of broadly applicable technical and organizational skills. We encourage applicants from historically underrepresented groups and from any disadvantaged socio-economic backgrounds. More information on the Subramaniam lab can be found by clicking this link . The goal of this postdoc research project is to use functional genomic approaches to discover and characterize novel mechanisms of mRNA translation in human cells. Our longer-term goal is to identify how these mechanisms are dysregulated across different tissue types and disease states. Thanks to methods such as ribosome profiling and RNA-seq, we have unprecedented genome-wide snapshots of gene expression at single nucleotide resolution. However, our ability to interrogate and predict the functional effects of mRNA sequence motifs on geneexpression and cell physiology has been limited. We aim to address this gap using:
The postdoctoral fellow will learn and apply cutting-edge deep sequencing approaches to identify novel sequence motifs and protein factors regulating mRNA translation in human cells. They will use targeted biochemical and genetic approaches to characterize the identified motifs and factors. They will learn and use computational methods to analyze large-scale sequencing data and formulate quantitative models. The fellow will have the opportunity to explore and bring novel approaches and ideas to their project by collaborating with other labs at Fred Hutch, including:
The fellow will present their work at group meetings and conferences, and write up their work for publication.
To apply, please submit the following materials
Graduate students getting ready to complete their PhD are encouraged to apply. We are proud to be an Equal Employment Opportunity (EEO) and Vietnam Era Veterans Readjustment Assistance Act (VEVRAA) Employer. We are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected. We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability (physical or mental), marital or veteran status, genetic information, sexual orientation, gender identity, political ideology, or membership in any other legally protected class. We are an Affirmative Action employer. We encourage individuals with diverse backgrounds to apply and desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to our Employee Services Center at hrops@fredhutch.org or by calling 206-667-4700. Application FAQs Software Powered by iCIMS
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