Postdoctoral Fellow

We are seeking a talented, motivated individual to lead the day-to-day activities of GEMINI, an NIH-funded study into the genetic basis of male infertility. The successful applicant will have a key role in exploring the large whole exome sequencing dataset generated from over 1000 cases to date and with another 1000 cases sequenced in the immediate future. The position requires the ability to organize and participate in periodic conference calls, the ability to independently design and execute computational analysis pipelines for genome sequence analysis, to perform follow-up validation experiments, and to travel and write papers to communicate analysis results.

Manage the day-to-day operations of the GEMINI Consortium

• Work independently with clinical collaborators to assist with enrollment, answer questions on logistics, schedule conference calls
• Maintain a local repository of DNA samples and distribute samples to collaborators and service providers as necessary
• Travel to academic conferences for face-to-face meetings as needed

Perform original research into the genetic basis of infertility

• Design and execute a computational pipeline to identify genetic variants from genome sequencing data, and interpret these variants.
• Perform follow-up experiments that will a) validate the presence of genetic variants predicted from whole-genome sequencing or b) characterize the functional impact of the genetic variant on a molecular or physiological level
• Communicate major research finding through teleconferences, conference presentations, and written reports and peer-reviewed papers.

Training and community-building

• Participate in the intellectual life of the lab and greater lab environment by attending seminars, lab meetings, and providing advice and training to others on an as-needed basis.

• Doctorate degree in Human Genetics, Genetics, or related quantitative science (e.g. biostatistics, computational biology)
• Previous success as a research scientist demonstrated by first-author publications
• Background in the application of statistical methods in the biological and medical sciences
• Strong computational skills
• Experience in Illumina-based short read sequence analysis
• Knowledge of basic experimental techniques used in human molecular genetics (e.g. cloning, Sanger sequencing).
• Ability to make critical decisions about lab operations independently
• Effective written and oral communication and proven ability to work in a collaborative environment

• Experience performing analysis of human exomes or genomes.

• Experience in a Linux/UNIX computing environment.

• Know a compiled language (e.g. C, Java), a scripting language (e.g. PERL, Python), and R.

Working conditions:

Works in laboratory environment with potential exposure to biological, chemical and radioactive hazards. Must be physically able to wear protective equipment. Must be able to travel less than 2 weeks per year.

Work schedule is routinely Monday through Friday, but requires ability to work flexible hours, as required by scope of the position.

Physical demands & equipment usage:

This job requires extensive work with a computer and could include sitting at a desk for long periods.

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