The Department of Ophthalmology and Visual Neurosciences at the University of Minnesota Medical School is inviting applications for a Researcher 5 on a recently funded NEI-R01 grant. The Lab studies the cellular and molecular mechanisms that regulate photoreceptor cell development, survival, opsin trafficking, retinoid metabolism, and molecular mechanisms of retinal cell and RPE degeneration in age related eye diseases, using cell culture, and mouse models, combined with cutting-edge molecular/cell biology and human genomics approaches. The successful candidate will join a dynamic and multidisciplinary research team investigating the molecular mechanisms of retinal cell degeneration and regeneration.
Designs, plans, and implements complex research projects, remains current on technological and scientific developments in the field and their potential application into experimental plans.
Use a range of information resources beyond the primary literature, e.g., public databases on gene expression, or genetically engineered animal models.
Understands models of biological processes, derives appropriate predictions from these models, and designs and conducts experiments to test those predictions. Carries out experiments independently from start to finish, trouble shoots, and optimizes methods.
Rapidly acquires knowledge of new methods as needed to complete projects.
Analyzes, interprets and presents complex experimental results.
Performs statistical analyses.
Serves as an expert resource to lab members, outside collaborators, and the scientific community in certain applications or areas of concentration, for example scRNA-seq or CRISPR methods.
Interacts, communicates, and coordinates with various parties, e.g., genomics core, bioinformatics, and collaborators, to complete research projects.
Suggests alternate methods, modifies or develops new procedures to aid in the completion of overall research goals.
Co-supervises and trains undergraduate and graduate students.
Discusses and plans new avenues of investigation.
Assists in drafting proposals to procure research funding.
Prepares manuscripts and figures for publication.
Writes or modifies IACUC protocols.
Assists with laboratory organization and compliance with all regulations.
The University of Minnesota offers a comprehensive benefits package including:
Competitive wages, paid holidays, vacation and sick leave
Low cost medical, dental, and pharmacy plans
Health care and dependent daycare flexible spending accounts
Excellent retirement plans with employer match
Disability and employer paid life insurance
Wellbeing program with reduced insurance premiums
Tuition reimbursement opportunities covering 75%-100% of eligible tuition
Applicants must possess an advanced degree in biomedical sciences (PhD or MD/PhD) with 1 or more years of research training.
PhD degree in the field of Ophthalmology, Biochemistry, Molecular Biology, or equivalent, with at least 3 years of postdoctoral research experience.
Prior first author publications and in-depth knowledge in one or more of the following research fields: protein trafficking, ophthalmology, retinal degenerative diseases, structural modeling, human genetics, or neurosciences.
Demonstrated ability to conduct experiments independently, to overcome complex technical challenges, and bring scientific projects to fruition in a self-motivated manner.
Expert knowledge in innovative experimental approaches, e.g., protein trafficking, protein purifications, 2-photon or confocal microscopy, HPLC analysis of retinoids, whole exome sequencing, and broad knowledge of in vitro and in vivo (mouse genetic) approaches.
Basic understanding of bioinformatic analysis workflows.
Experience in manuscript writing and presentations at scientific conferences.
Internal Number: 338716
About University of Minnesota, Twin Cities
The University of Minnesota, founded in the belief that all people are enriched by understanding, is dedicated to the advancement of learning and the search for truth; to the sharing of this knowledge through education for a diverse community; and to the application of this knowledge to benefit the people of the state, the nation, and the world.