Washington University is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, genetic information, disability, or protected veteran status.
Department Name/Job Location:
This position is in the Department of Radiation Oncology. This position is for the Medical School Campus.
The Washington University School of Medicine, Department of Radiation Oncology has an opening for a post-doctoral research associate in the Division of Cancer Biology in the Laboratory of Julie Schwarz, MD, PhD. The laboratory projects will involve preclinical modeling of chemotherapy and radiation induced oxidative stress in tumor cells as well as the associated tumor microenvironment. The primary tumor model systems used will include orthotopic syngeneic, patient derived xenograft and genetically engineered models of gynecologic and non gynecologic (Human Papilloma Virus) HPV associated cancers. This position also includes collaborative work in other tumor sites and focused study of normal tissue effects. A corresponding well annotated prospectively collected human tumor bank provides an outstanding resource for corresponding translational studies using advanced bioinformatic technologies.
Current projects: (1) Generation of novel immune competent genetically engineered mouse models of HPV associated cancers; (2) Treatment response modeling using patient derived xenograft models; (3) Tumor metabolism studies including tumor intrinsic and extrinsic (i.e., tumor microenvironment) utilization of glucose, glutamine and free fatty acids before and after chemotherapy and radiation; (4) Radiation and chemotherapy associated remodeling of the tumor microenvironment including focused study of the effects on local and systemic anti-tumor immunity.
PRIMARY DUTIES AND RESPONSIBILITIES:
Actively pursue research under the supervision of the PI while developing skills for independent research.
Critically analyze and summarize scientific literature.
Develop research questions, design and conduct experiments, and critically analyze data.
Communicate methods, data, and results in presentations and via manuscript writing.
Assist with grant preparation.
Ph.D. (or equivalent degree) in radiation biology, cancer biology, immunology, molecular biology or a related field.
Extensive experience in molecular biology techniques, including both in vitro and in vivo work as well as outstanding scientific communication skills including oral presentations and manuscript preparation.
Additional experience with advanced techniques to study tumor metabolism (mass spectrometry, isotope labeling, metabolic flux studies) and/or tumor immunology (ELISA, flow cytometry, single cell sequencing).
Post Doc Instructions:
Please do not submit an application to this posting.� To apply for this postdoctoral research opportunity, follow the directions below in �Applicant Special Instructions�.
Base pay commensurate with experience.
All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. Current employees applying for a new position within the university may be subject to this requirement. The screenings will include a criminal background check and, as applicable for the position, other background checks, drug screen, employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening.
Please attach a copy of your most current signed performance evaluation (completed within the last 18 months) to your online account. If you have not received a performance evaluation, you may provide two current signed letters of recommendation (written within the last 18 months), preferably to include one letter from either a current or recent former supervisor. To attach these documents, go to: My Career Tools, Add Attachment, Attachment Type – Performance Reviews or Letters of Recommendation.
Applicant Special Instructions:
Interested candidates should send a cover letter (brief) and curriculum vitae to Dr. Julie Schwarz at firstname.lastname@example.org.
Washington University in St. Louis, a medium-sized, independent university, is dedicated to challenging its faculty and students alike to seek new knowledge and greater understanding of an ever-changing, multicultural world. The University offers more than 90 programs and almost 1,500 courses leading to bachelor's, master's and doctoral degrees in a broad spectrum of traditional and interdisciplinary fields, with additional opportunities for minor concentrations and individualized programs. The faculty is composed of scholars, scientists, artists and members of the learned professions. They serve society by teaching; by adding to the store of human art, creativity, understanding, and wisdom; and by providing direct services, such as health care.