Why Work at BNL? Brookhaven National Laboratory (www.bnl.gov) delivers discovery science and transformative technology to power and secure the nation's future. Brookhaven Lab is a multidisciplinary laboratory with seven Nobel Prize-winning discoveries, 37 R&D 100 Awards, and more than 70 years of pioneering research. The Lab is primarily supported by the U.S. Department Energy's (DOE) Office of Science. Brookhaven Science Associates (BSA) operates and manages the Laboratory for DOE. BSA is a partnership between Battelle and The Research Foundation for the State University of New York on behalf of Stony Brook University.
CSI has an opening for a post-doc to participate in multi-disciplinary development of new tools to facilitate sequence-to-function discovery. BNL is the home to several state-of-art research facilities, including synchrotron beamlines at NSLS-II (https://www.bnl.gov/ps/lifesciences/), cryo-EM at the new Laboratory for BioMolecular Structures (LBMS, https://www.bnl.gov/cryo-em/), and computation at the Computational Science Initiative (CSI, https://www.bnl.gov/compsci/). We have initiated a project, with participation from investigators from Biology Department, CSI, LBMS and NSLS-II, to develop integrative data analysis to maximize the impact of the data collected at the BNL facilities. More specifically, computation and modeling will be used to help put in context multi-scale data from different experimental methods, including crystallography, solution scattering, and cryo-EM. Together with other team members, the candidate will carry out proof-of-concept research using a series of pre-selected test cases, including determining mechanistic understanding for a novel nucleotide-dependent fungal zinc transferase involved in protein biogenesis and studying the dynamics of heme-zinc cooperativity in a newly discovered cyanobacterial heme protein. This work will help establish standard workflows that will become more broadly applicable to user projects at NSLS-II and LBMS. The long-term goal is to eventually establish a new research center that interfaces external users with the research capabilities at BNL. This position has a two-year term. Extension to a third year will depend on satisfactory performance and funding.
Essential Duties and Responsibilities:
Understand the scientific requirements and current state of the field
Develop multi-scale modeling and other relevant tools for integrative data analysis
Work with colleagues to analyze data
Required Knowledge, Skills, and Abilities:
Ph.D. in molecular biology, computational biology, or a related field
Experience using multi-scale structural modeling (e.g., molecular dynamics and coarse-grained simulations) to study molecular flexibility and interaction
Experience in collaborative software development in support of structural biology research
Manuscript writing and demonstrated track record of publication
Self-motivation and ability to work in a diverse team environment
Preferred Knowledge, Skills, and Abilities:
Experience with integrative data analysis in structural biology that involve data from multiple experimental techniques
Experience in developing applications designed to run on high performance computing systems.
OTHER INFORMATION: (add if applicable)
Moderate domestic and foreign travel
BNL policy requires that research associate appointments be made to individuals who have received their doctorate within the past five years.
At Brookhaven National Laboratory we believe that a comprehensive employee benefits program is an important and meaningful part of the compensation employees receive. Our benefits program includes, but is not limited to:
Brookhaven National Laboratory (BNL) is an equal opportunity employer that values inclusion and diversity at our Lab. We are committed to ensuring that all qualified applicants receive consideration for employment and will not be discriminated against on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, age, status as a veteran, disability or any other federal, state or local protected class.
BNL takes affirmative action in support of its policy and to advance in employment individuals who are minorities, women, protected veterans, and individuals with disabilities. We ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.
*VEVRAA Federal Contractor
Internal Number: 2476
About Brookhaven National Laboratory
Brookhaven National Laboratory is a multipurpose research institution funded primarily by the U.S. Department of Energy’s Office of Science. Located on the center of Long Island, New York, Brookhaven Lab brings world-class facilities and expertise to the most exciting and important questions in basic and applied science—from the birth of our universe to the sustainable energy technology of tomorrow. We operate cutting-edge large-scale facilities for studies in physics, chemistry, biology, medicine, applied science, and a wide range of advanced technologies. The Laboratory's almost 3,000 scientists, engineers, and support staff are joined each year by more than 4,000 visiting researchers from around the world. Our award-winning history, including seven Nobel Prizes, stretches back to 1947, and we continue to unravel mysteries from the nanoscale to the cosmic scale, and everything in between. Brookhaven is operated and managed by Brookhaven Science Associates, which was founded by the Research Foundation for the State University of New York on behalf of Stony Brook University, and Battelle, a nonprofit applied science and technology organization.