Research Fellow

There is an immediate opening for a Postdoctoral Fellow in Qi group at the Dana-Farber Cancer Institute to look for exceptional Postdoctoral Fellows in Chemistry and Chemical Biology field. The Qi lab studies gene regulatory pathways using the emerging discipline of chemical biology. Successful candidates will work with an interdisciplinary team of scientists including medicinal chemists, biochemists, computational biologists, and cancer biologists to develop novel inhibitors of chromatin modifying enzymes, such as methyltransferases, demethylases as well as other epigenetic targets and transcription factors. The successful candidate will perform research that establish fundamental insights to cancer biology using novel small molecule inhibitors to gain mechanistic understanding in cancer therapy.  We expect that novel therapeutics for human clinical investigation will emerge directly from these efforts through academic/industry collaborations.

Located in Boston and the surrounding communities, Dana-Farber Cancer Institute brings together world renowned clinicians, innovative researchers and dedicated professionals, allies in the common mission of conquering cancer, HIV/AIDS and related diseases. Combining extremely talented people with the best technologies in a genuinely positive environment, we provide compassionate and comprehensive care to patients of all ages; we conduct research that advances treatment; we educate tomorrow's physician/researchers; we reach out to underserved members of our community; and we work with amazing partners, including other Harvard Medical School-affiliated hospitals.

We are seeking an enthusiastic, self-motivated, and experienced bench-level synthetic chemist who is willing to learn multi-discipline approach for cancer research to join Qi Lab. The major focus of this position will include developing and executing design and synthesis small molecule inhibitors while investigating novel biological mechanisms of action of inhibitors in cancer with team.

 Specific responsibilities include:

• Performing synthesis and development of small molecule inhibitors under structure guidance.
• Experience in computational modeling is a plus.
• Performing laboratory experiments and conducting data analysis.
• Collaborating with team members and collaborators to understand the target inhibition in different cancers.
• Designing experiments and executing protocols.
• Maintaining accurate records, writing reports, and preparing/giving presentations.
• Chemical biology/Biology background is preferred but not required.

• PhD in chemistry, medicinal chemistry, chemical biology or equivalent
• A strong understanding in biochemistry, chromatin biology, cancer biology is preferred, but not required.
• Excellent oral and written communication skills.
• The ability to perform both self-directed and guided research is required.
• Must demonstrate outstanding ability to work effectively as part of an interdisciplinary team of scientists.

The postdoctoral fellow will be affiliated with the Department of Cancer Biology at Dana-Farber Cancer Institute, the Department of Medicine at Harvard Medical School and the Broad Institute.

Dana-Farber Cancer Institute is an equal opportunity employer and affirms the right of every qualified applicant to receive consideration for employment without regard to race, color, religion, sex, gender identity or expression, national origin, sexual orientation, genetic information, disability, age, ancestry, military service, protected veteran status, or other groups as protected by law.