Washington University is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, sexual orientation, gender identity or expression, national origin, genetic information, disability, or protected veteran status.
Post Doc Instructions:
Please do not submit an application to this posting. To apply for this postdoctoral research opportunity, follow the directions below in “Applicant Special Instructions”.
Internal Applicant Instruction:
Please attach a copy of your most current signed performance evaluation (completed within the last 18 months) to your online account. If you have not received a performance evaluation, you may provide two current signed letters of recommendation (written within the last 18 months), preferably to include one letter from either a current or recent former supervisor. To attach these documents, go to: My Career Tools, Add Attachment, Attachment Type – Performance Reviews or Letters of Recommendation.
Department Name/Job Location:
This position is in the Department of Internal Medicine, Division of Oncology. This position is for the Medical School Campus.
There is an opportunity for research in the laboratory of Dr. Grant Challen, which studies how genetic mutations influence the function of blood-forming stem cells in the bone marrow (hematopoietic stem cells = ‘”HSCs”) and contribute to the development of blood cancers such as myelodysplastic syndromes (= “MDS”), myeloproliferative neoplasms (= “MPN”), acute myeloid leukemia (= “AML”) and T-cell acute lymphoblastic leukemia (= “T-ALL”). The Challen lab is using cutting-edge techniques such as next-generation sequencing, CRISPR/Cas9 and high-throughput flow cytometry to investigate these processes in model systems incorporating cancer cell lines, transgenic mouse models, and primary cells from human patients. The overall goal of the lab is to understand how different processes contribute to turning a normal stem cell into cancer, with the aim of identifying new treatment approaches for patients with blood cancers.
The successful candidate will have the opportunity to work on any number of projects investigating how epigenetic modifications influence HSC fate decisions, and how genetic mutations in epigenetic regulators contribute to clonal expansion of mutant HSCs in clonal hematopoiesis, and predispose for transformation to hematopoietic malignancies.
The post-doctoral associate will be responsible for managing their own projects (under the mentorship of Dr. Challen) as well as contributing to ongoing projects with other trainees.
For more information about our lab research, please visit our website (www.challenlab.com) and follow us on Twitter (@challenlab).
Ph.D. and/or M.D. degree.
Independent analytical thinking and research planning skills.
Demonstrated ability to work independently and communicate with the laboratory staff and investigators.
Prior experience in molecular biology is a plus.
Experience in cell/tissue culture experiments, RNA/DNA preparation and expression.
Ability to maintain complete and organized records/reports.
Working knowledge of computer software and general lab equipment.
Experience in flow cytometry and small animal handling is desirable.
Willingness to learn these techniques.
Base pay commensurate with experience.
All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. Current employees applying for a new position within the university may be subject to this requirement. The screenings will include a criminal background check and, as applicable for the position, other background checks, drug screen, employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening.
Washington University in St. Louis, a medium-sized, independent university, is dedicated to challenging its faculty and students alike to seek new knowledge and greater understanding of an ever-changing, multicultural world. The University offers more than 90 programs and almost 1,500 courses leading to bachelor's, master's and doctoral degrees in a broad spectrum of traditional and interdisciplinary fields, with additional opportunities for minor concentrations and individualized programs. The faculty is composed of scholars, scientists, artists and members of the learned professions. They serve society by teaching; by adding to the store of human art, creativity, understanding, and wisdom; and by providing direct services, such as health care.