The Postdoc will develop machine learning algorithms tailored to the needs ofsynthetic biology, enabling the production ofrenewable bioproducts through predictive bioengineering. The Postdoc will work as part of a collaborative team to integrate microbial phenotypic data (e.g. fluxomics, transcriptomics, proteomics, metabolomics) into quantitative computational models able to predict and explain the outcomes of bioengineering interventions. The Postdoc will work closely with an interdisciplinary team of bench scientists, automation engineers and software developers in devising methods for high-throughput data collection and analysis for feedback into experimental design, as part of theAgile BioFoundryor theJoint BioEnergy Institute.
What You Will Do:
Integrate and analyze data.
Develop quantitative predictive models of cell metabolism.
Use machine-learning and data-mining approaches to improve bioproduct yields.
Integrate transcriptomic, proteomic and metabolomic data into quantitative models.
Use Monte Carlo approaches to more precisely measure and predict metabolic fluxes.
Develop and optimize code and algorithms for predictive models.
Calculate metabolic flux distributions from carbon labeling data and flux balance analysis.
Develop and validate kinetic models for bacterial and yeast metabolism.
Interact continuously with experimentalists to guide and propose new experiments and use available data to its full potential.
Deal with problems that may affect the achievement of research objectives and deadlines.
Prepare research results for publication and for presentations at scientific and internal meetings.
Additional Responsibilities as needed:
Assist in the preparation of grant proposals.
What is Required:
PhD in systems biology, bioengineering, computational biology, bioinformatics, applied mathematics, theoretical physics, computer science, electrical engineering or closely related discipline.
Significant experience in python or other major programming languages.
Strong mathematical background and analytical skills.
Research experience demonstrated through successful publications.
Strong interest in microbiology and bacterial metabolism.
Proven experience in Linux including file systems, shell, hardware/software monitoring, etc.
Effective interpersonal and communication skills (including written and presentational).
The ability to work and think independently and to contribute to the planning of a program of scientific research.
Effective organizational skills and the ability to prioritize work to meet deadlines.
Evidence of an ability to write to a standard required for research reports/publications.
A commitment to and demonstrated ability to perform collaborative research in an interdisciplinary team environment.
Additional Desired Qualifications:
Knowledge of microbiology and bacterial metabolism.
Experience in metabolic flux analysis.
Experience on experimental lab work.
The posting shall remain open until the position is filled.
This is a full time 2-year postdoctoral appointment with the possibility of renewal based upon satisfactory job performance, continuing availability of funds and ongoing operational needs. You must have less than 3 years of paid postdoctoral experience.
M-F, exempt (monthly paid) from overtime pay.
This position is represented by a union for collective bargaining purposes.
Salary will be predetermined based on postdoctoral step rates.
This position may be subject to a background check. Any convictions will be evaluated to determine if they directly relate to the responsibilities and requirements of the position. Having a conviction history will not automatically disqualify an applicant from being considered for employment.
Work will be primarily performed at: Joint BioEnergy Institute (JBEI) -- Bldg. 978, 5885 Hollis St., 4th floor, Emeryville, CA.
Learn about us!
Biological Systems and Engineering Division
Vision: To lead efforts that combine the power of biology with the tools of engineering to develop sustainable energy and biomanufacturing solutions and improve human health.
Mission:Advance a mechanistic and predictive understanding of complex biological systems over multiple scales in terms of their responses to manipulation, stress, disease and environmental challenges and translate this knowledge using engineering principles to develop resilient systems, tools, and processes for the efficient production of fuels, chemicals, materials, tissues, and therapeutics.
Berkeley Lab (LBNL) addresses the world's most urgent scientific challenges by advancing sustainable energy, protecting human health, creating new materials, and revealing the origin and fate of the universe. Founded in 1931, Berkeley Lab's scientific expertise has been recognized with 13 Nobel prizes. The University of California manages Berkeley Lab for the U.S. Department of Energy's Office of Science.
Working at Berkeley Lab has many rewards including a competitive compensation program, excellent health and welfare programs, a retirement program that is second to none, and outstanding development opportunities. To view information about the many rewards that are offered at Berkeley Lab- Click Here.
Equal Employment Opportunity: Berkeley Lab is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, or protected veteran status. Berkeley Lab is in compliance with the Pay Transparency Nondiscrimination Provision under 41 CFR 60-1.4. Click here to view the poster and supplement: "Equal Employment Opportunity is the Law.
Lawrence Berkeley National Laboratory encourages applications from women, minorities, veterans, and other underrepresented groups presently considering scientific research careers.
Internal Number: 91075
About Lawrence Berkeley National Laboratory
In the world of science, Lawrence Berkeley National Laboratory (Berkeley Lab) is synonymous with excellence. Thirteen scientists associated with Berkeley Lab have won the Nobel Prize. Fifty-seven Lab scientists are members of the National Academy of Sciences (NAS), one of the highest honors for a scientist in the United States. Thirteen of our scientists have won the National Medal of Science, our nation's highest award for lifetime achievement in fields of scientific research. Eighteen of our engineers have been elected to the National Academy of Engineering, and three of our scientists have been elected into the Institute of Medicine. In addition, Berkeley Lab has trained thousands of university science and engineering students who are advancing technological innovations across the nation and around the world. Berkeley Lab is a member of the national laboratory system supported by the U.S. Department of Energy through its Office of Science. It is managed by the University of California (UC) and is charged with conducting unclassified research across a wide range of scientific disciplines. Located on a 200-acre site in the hills above the UC Berkeley campus that offers spectacular... views of the San Francisco Bay, Berkeley Lab employs approximately 4,200 scientists, engineers, support staff and students. Its budget for 2011 is $735 million, with an additional $101 million in funding from the American Recovery and Reinvestment Act, for a total of $836 million. A recent study estimates the Laboratory's overall economic impact through direct, indirect and induced spending on the nine counties that make up the San Francisco Bay Area to be nearly $700 million annually. The Lab was also responsible for creating 5,600 jobs locally and 12,000 nationally. The overall economic impact on the national economy is estimated at $1.6 billion a year. Technologies developed at Berkeley Lab have generated billions of dollars in revenues, and thousands of jobs. Savings as a result of Berkeley Lab developments in lighting and windows, and other energy-efficient technologies, have also been in the billions of dollars. Berkeley Lab was founded in 1931 by Ernest Orlando Lawrence, a UC Berkeley physicist who won the 1939 Nobel Prize in physics for his invention of the cyclotron, a circular particle accelerator that opened the door to high-energy physics. It was Lawrence's belief that scientific research is best done through teams of individuals with different fields of expertise, working together. His teamwork concept is a Berkeley Lab legacy that continues today.