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POSTDOCTORAL SCHOLAR
University of Iowa
About the Stead Family Department of Pediatrics and University of Iowa Stead Family Children's Hospital The Stead Family Department of Pediatrics is a national leader in pediatric medicine. The Department's mission is to provide outstanding care to the children of Iowa and beyond by being a leader in state-of-the-art clinical care to children, performing cutting-edge research to find new treatments and cures for childhood illnesses, and educating the next generation of pediatric health care providers. The Department comprises the medical and research staff of UI Stead Family Children's Hospital. UI Stead Family Children's Hospital is one of the nation's top-ranked pediatric care and research institutions, and Iowa's only comprehensive children's hospital. A new free-standing Children's Hospital opened in 2017. Division of Pediatric Pulmonary Medicine, Allergy, and Immunology The laboratory is performing a variety of gene transfer studies using lentiviral and transposon vectors. We have developed novel lentiviral vector pseudotypes that target receptors on the apical surface of airway epithelia. We are also exploring other nucleic acid based interventions including RNA interference and gene editing for therapeutic purposes. In addition we are investigating genomics approaches such as the connectivity map to identify small molecules to rescue CFTR function. A long-term goal is to develop vector systems with that can be successfully used in children to treat or prevent CF lung disease by gene addition or gene repair. Position Summary The candidate will assist with research efforts on the preclinical development of novel gene therapies for cystic fibrosis. We seek a candidate with proven ability to work independently and collaboratively to achieve project goals. The candidate will be expected to generate novel ideas to overcome barriers to vector delivery. The ultimate goal is the generation of products that will benefit patients. Position Responsibilities
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