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Post Doc Instructions:
Please do not submit an application to this posting.� To apply for this postdoctoral research opportunity, follow the directions below in �Applicant Special Instructions�.
Department Name/Job Location:
This position is in the Department of Internal Medicine, Division of Infectious Diseases. This position is for the Medical School Campus.
We are looking for enthusiastic Post-docs to study antibody-mediated immunity to influenza virus. The goal of the project is to investigate the impact of host genetic variation and prior infections on the antibody response and repertoire after influenza vaccination. The techniques for this project include single-cell sequencing, mouse genetics, and antibody-based assays, such as ELISA and virus neutralization assays.
In the Boon lab at Washington University in Saint Louis, Missouri, USA, we study influenza virus and influenza pathogenesis. We want to understand how the segmented genome of the virus assembles and how this process affects the outcome of virus reassortment, and thus the generation of pandemic viruses. Our work has led to the discovery of several RNA structures in the viral genome that are necessary for inter-segment RNA interactions and genome packaging (Williams et. al, Nature Communications, 2018). Currently we are identifying and investigating these structures in avian, human and swine influenza viruses and study their role on genome reassortment. Our lab also studies viral pathogenesis with the goal to identify host factors or host proteins that exacerbate inflammation and disease after highly pathogenic influenza infection. We found that the expression of IFI35 (Gounder et. al, PLoS Pathogens, 2018) increases the production of pro-inflammatory cytokines, and causes additional weight loss and disease after influenza infection. Future studies aim to elucidate the intracellular mechanism by which IFI35 regulates cytokine gene expression, and dissect the role of IFI35 during other microbial pathologies.
The laboratory is part of the Division of Infectious Diseases at Washington University School of Medicine in St Louis (https://infectiousdiseases.wustl.edu). The division is home to clinical and basic science investigators and promotes translational and clinical research. The laboratory is housed on the medical campus together with many other labs studying host-pathogen interactions. We also have access to an enhanced biosafety level 3 laboratory. The work environment is very collaborative and there are many opportunities to work with colleagues in other disciplines. Washington University also has an active Office of Postdoctoral Affairs and is an equal opportunity employer. Information on being a postdoc at Washington University in St. Louis can be found at postdoc.wustl.edu/prospective-postdocs.
PhD in molecular biology, genetics, microbiology, immunology or a similar field.
Published in high-quality peer-reviewed journals.
Ability to guide research projects and maintain detailed records of experimental work.
A background in or strong desire to learn bioinformatics analysis techniques.
Good interpersonal skills and willingness to mentor students and technicians.
Excellent speaking, reading and writing skills.
PhD in Biochemistry, Molecular Biology or Biophysics.
Base pay commensurate with experience.
All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. Current employees applying for a new position within the university may be subject to this requirement. The screenings will include a criminal background check and, as applicable for the position, other background checks, drug screen, employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening.
To apply for this position, please apply above or send a cover letter, CV, contact info for three references and one key first author publication directly to email@example.com.
Jacco Boon, PhD
Washington University School of Medicine firstname.lastname@example.org
Internal Applicant Instruction:
Please attach a copy of your most current signed performance evaluation (completed within the last 18 months) to your online account. If you have not received a performance evaluation, you may provide two current signed letters of recommendation (written within the last 18 months), preferably to include one letter from either a current or recent former supervisor. To attach these documents, go to: My Career Tools, Add Attachment, Attachment Type – Performance Reviews or Letters of Recommendation.
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