Columbia University's Department of Medicine invites applications for a research position in the rank of Postdoctoral Research Scientist at The Columbia University Irving Medical Center in the Division of Molecular Medicine in the Laboratory of Dr. Ira Tabas. The position includes both laboratory and translational research.
Summary Description: Our laboratory studies the cellular biology of cardiometabolic disease, with an emphasis on the molecular-cellular mechanisms of advanced atherosclerosis and hepatic insulin resistance and non-alcoholic steatohepatitis (NASH) in obesity, and the links between these processes.
We are seeking a talented postdoctoral research scientist with interest and expertise in molecular-cellular mechanisms related to cardiometabolic disease, insulin resistance, and NASH, including metabolic studies in obese diabetic mice. Priority will be given to candidates who have experience in these areas, particularly in conducting metabolic analyses in obese mice.
The selected candidate will work conduct research on the following projects:
Advanced atherosclerosis have focused on integrated processes that combine to promote advanced plaque progression, with the current focus on defective clearance of the apoptotic cells (efferocytosis) and impaired inflammation resolution. In the efferocytosis field, we study (a) a macrophage receptor called MerTK; and (b) a process called high-burden efferocytosis, whereby a macrophage ingests and degrades multiple apoptotic cells over a short time period, requiring reprogramming of vesicular trafficking pathways and metabolism of molecules from degraded apoptotic cells. The inflammation resolution project investigates cellular mechanisms of the resolution process and its therapeutic potential, e.g., through the use of atherosclerosis-targeted nanoparticles packaged with resolution mediators. An exciting new area in the lab involves identifying specific mechanistic links between impaired resolution pathways and clonal hematopoiesis of indeterminate potential (CHIP), which is a major risk factor for atherosclerosis and coronary artery disease in humans over the age of 60.
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