| Requisition Number: 2019 - 258 Business Unit: Eppley Institute Department: Eppley Inst Research 50000686 Reg-Temp: Full-Time Regular Position Summary: Research projects will involve studies in B-cell malignancies (e.g., chronic lymphocytic leukemia; CLL) including disease biology, tumor microenvironment (TME) interactions, immune (dys)function as well as pre-clinical evaluation of novel targeted therapies such as novel small molecule inhibitors targeting B-cell specific kinases and the bromodomain and extra-terminal (BET) family proteins. Pre-clinical evaluations of these novel therapeutics in primary cells, cell lines and/or mouse models will include evaluating their therapeutic benefits, their ability to modulate TME interactions and immune function in CLL, and potential resistance mechanism.
Interested candidates should provide us with most recent CV (including contact information for 3 referees) and statement of research interests Required Qualifications: Candidates should have PhD in cancer biology, immunology or related field. Basic and advanced molecular biology techniques (e.g., PAGE, WB, ELISA, molecular cloning, plasmid vectors engineering, transfection, and extraction of RNA,DNA and protein etc) flow cytometry (experimental/panel design and analysis) and sterile cell culture techniques including primary cell isolation. Supplemental Qualifications: Background in hematological malignancies as well as experience working with mouse models to evaluate novel therapies and cancer immunology is highly preferred.
The candidate should be extremely motivated with excellent English skills both oral and written. For further details on the nature of our lab’s research, these articles are recommended; PMID: 29386193, PMID: 25001469, PMID: 24413321 and PMC5320964. To read more about the lab, visit https://unmc.edu/eppley/about/faculty/elgamal.html
Other qualifications are: Use of bioinformatic tools for analysis and interpretation of omics data (e.g. RNA-seq, ATAC-seq, proteomics) and genome editing Salary Range: Salary Commensurate with Experience | 
