| Chemistry Research Specialist England Laboratory University of California, San Francisco The England Laboratory within the Department of Pharmaceutical Chemistry seeks candidates with expertise in synthetic organic chemistry for a Specialist research position. Qualified applicants will be hired at the Junior, Assistant, or Associate level, depending upon the candidate’s experience. Dr. England’s research is focused on developing and utilizing chemical tools to decode biology and advance medicine. The laboratory is currently developing synthetic small molecules to control the activity of nuclear receptors, a class of intracellular proteins that regulate gene expression in response to endogenous hormones and other small molecules. These receptors play critical roles in human development, physiology, and disease and have proven to be effective therapeutic drug targets. Under general direction, the incumbent will develop and study the activity of ligands targeting the nuclear receptor Nurr1, a potential therapeutic target for Parkinson’s disease, and LRH-1, a potential therapeutic target for several cancers. Applicants are expected to be able to work independently and possess the ability to read and digest literature surrounding the project, and to troubleshoot experiments when they don’t work. In addition, the applicant must possess the ability to analyze their data and clearly communicate their research techniques and results in written and oral formats suitable for publication. Specific activities associated with the position include, but are not limited to, the following: - Chemical synthesis of small molecules. Technical skill set: anhydrous techniques, assembly of chemical reactions, purification of crude products via column chromatography, analysis of purified material via LC-MS and
- In vitro biophysical assays of ligand affinity: Technical skill set: differential scanning fluorimetry assays (DSF), microscale thermophoresis assays (MST), surface plasmon resonance (SPR)
Required Qualifications - Specialists appointed at the Junior rank must possess a baccalaureate degree (or equivalent degree).
- Specialists appointed at the Assistant or Associate rank must possess a master’s degree (or equivalent degree) or five to ten years of research
- Two or more years prior experience conducting laboratory research
- Excellent organizational skills
- Excellent written and verbal presentation skills
- Experience with ChemDraw, graphing software (e.g. Excel, Prism or KaleidaGraph) and statistical analyses, powerpoint or other oral presentation
- Applicants must list all of the basic qualifications (or if pending) on their CV and/or cover letter upon
- Candidates must meet the requirements by the time of
Preferred Qualifications - PhD (or equivalent level of experience) in synthetic chemistry, chemical biology, biochemistry, or equivalent
Please apply online at https://aprecruit.ucsf.edu/JPF02873, with a CV, cover letter, and two references (contact information only). UC San Francisco seeks candidates whose experience, teaching, research, or community service that has prepared them to contribute to our commitment to diversity and excellence. The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status. |
