A cardiovascular genomics lab is seeking talented Postdoctoral Research Fellow candidates for human genetics studies that we are extending into in vitro and animal models of vascular disease (fibromuscular dysplasia, arterial dissection and aneurysm, a primary manifestations of arterial fibroplasia and aberrant vascular remodeling). In the lab, we perform gene discovery studies using genome sequencing, GWAS and transcript expression profiling methods to understand both common and rare vascular diseases. We use in vitro cellular and in vivo models to assess the functional significance of our genomic discoveries, and currently we have novel findings which we are modeling. We are performing ribosomal translation affinity and purification analyses in our disease mouse models, to generate and refine hypotheses regarding the genetic mechanism of disease. Current genetic investigations are focused on vascular smooth muscle cell transcription, arterial extracellular matrix, and the vascular phenotype of specific diseases such as Neurofibromatosis. Our studies are closely tied to the clinic, with human tissue and blood samples from meticulously phenotyped patients and thus candidates can expect to gain exposure to human genetics and translational aspects of their research projects.
The laboratory has multiple NIH and non-NIH sources of funding.
The Candidates should hold a Ph.D. and have publications in genomics, molecular genetics or vascular biology fields with an interest in human genetics, ideally with prior experience with mouse models. The ideal candidate is highly motivated to learn solid scientific methods and to write manuscripts and grant applications.
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Internal Number: 172255
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