Human Neuronal Differentiation Core (HNDC) is looking for a highly motivated Postdoctoral Scholar to join a research program investigating the molecular basis of neurodevelopmental and neurodegenerative disorders. HNDC supports studies of multiple research groups including those supported through the Intellectual and Developmental Disabilities Research Center (IDDRC). We are using directed differentiation and direct conversion of human pluripotent stem cells (embryonic and patient-derived induced pluripotent stem cells) for application of a wide range of molecular and genetic modifiers to human neurons and elucidation of underlying regulatory gene networks behind the cell phenotype.
HNDC is part of the Department of Molecular and Human Genetics, an internationally recognized department at Baylor College of Medicine. The core facility is at the Neurological Research Institute of the Texas Children's Hospital, a multidisciplinary and extremely dynamic research environment with state-of-art infrastructure (https://nri.texaschildrens.org/core-facilities). In order to support the ongoing projects, the selected candidate will work directly with students and postdocs to design and conduct electrophysiology (patch-clamp and MEA) and calcium imaging experiments using human 2D and 3D neuronal models and investigating contributions of various cells types in neural disease.
This opportunity is ideal for a candidate who desires to build his/her resume either by increasing personal bibliography output or documenting skills relevant for transitioning to industry.
Education: Ph.D in Basic Science, Health Science, or a related field.
Training and independence in performing experiments with at least one of the following methods: whole cell patch-clamping and calcium imaging.
A preference will be given to applicants with the following experience: iPSC-derived neurons or primary neuronal cultures and organotypic slices, immunohistochemistry and confocalmicroscopy, multi-electrode array recordings.
A strong interest in and research training relevant to the areas of stem cell biology and neural development.
Planning and performing advanced research experiments.
Establishing new research protocols and procedure.
Writing reports on analysis of acquired data.
Summarizing findings and assisting with figures for grant proposals and manuscripts.
May be responsible for laboratory management.
May supervise research staff.
Essential personal qualities important for this job include sense of responsibility, excellent organizational skills, clear and effective verbal/written communication, interest in working in a dynamic setting with various groups, and unfailing desire to understand the brain.
Telecommuting is allowed.
Internal Number: 2128
About Baylor College of Medicine
Texas Children's Hospital and Baylor College of Medicine opened the Jan and Dan Duncan Neurological Research Institute (NRI) in 2011. Building on our considerable strengths in genetics, neuroscience and pediatrics, the Duncan NRI is designed to foster a multidisciplinary, collaborative environment that will facilitate fundamental discoveries in neuroscience with the ultimate goal of translating them to therapies for many incurable neurological and neurodegenerative conditions. Currently the Duncan NRI is home to more than 25 principal investigators and 200 scientists in 10 core labs, including the Gordon and Mary Cain Pediatric Neurology Research Foundation for epilepsy research. Since inception, more than 300 scientific studies have been published, more than 40 disease-causing genetic mutations have been discovered or co-discovered by our scientists, and promising clinical trials for Rett syndrome and tuberous sclerosis complex have been launched as a result of our research.