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The Kalantry Lab in the Department of Human Genetics at the University of Michigan Medical School is seeking a postdoctoral fellow to join our interdisciplinary and highly interactive laboratory team focused on elucidating principles of epigenetic inheritance primarily, but not exclusively, through the study of X-chromosome inactivation. X-inactivation is an evolutionarily conserved paradigm of epigenetic regulation that equalizes X-linked gene expression between male and female mammals by silencing genes on one of the two X-chromosomes in females. X-inactivation lies at the nexus of functional long noncoding (lnc) RNAs and chromatin-modifying factors.
The Kalantry Lab has discovered new lncRNAs and identified chromatin modifying proteins with previously unknown functions in X-inactivation. Projects involve genetically and biochemically testing lncRNAs and chromatin modifiers in initiating and/or maintaining X-inactivation in cultured stem cells and in mice as well as discovering novel factors and mechanisms underlying X-inactivation. Postdoctoral fellows will have opportunities to take projects with them to their independent positions.
Work closely with others in the laboratory to genetically and epigenetically dissect X-chromosome inactivation in a variety of model systems, including mouse, rat, and human stem cells and mouse and rat embryos.
Take initiative and develop new concepts and techniques.
Read the relevant scientific literature deeply.
Attend and present seminars and participates in joint lab meetings.
Prepare manuscripts for publication and present findings at national meetings.
Ph.D. in genetics and/or epigenetics or related fields.
Expertise in molecular biology, cell culture, and/or biochemistry.
Highly motivated, organized individual with a demonstrated track record of innovation and independent direction.
Ability to work collaboratively, take initiative, and complete projects.
A strong publication record with one or more first-author publication(s).
Ability to analyze high-throughput datasets.
Experience with advanced statistical methods.
Michigan Medicine conducts background screening and pre-employment drug testing on job candidates upon acceptance of a contingent job offer and may use a third party administrator to conduct background screenings. Background screenings are performed in compliance with the Fair Credit Report Act. Pre-employment drug testing applies to all selected candidates, including new or additional faculty and staff appointments, as well as transfers from other U-M campuses.
Job openings are posted for a minimum of seven calendar days. The review and selection process may begin as early as the eighth day after posting. This opening may be removed from posting boards and filled anytime after the minimum posting period has ended.
The University of Michigan is an equal opportunity/affirmative action employer.
Internal Number: 176091
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