A position is available for a highly motivated Research Specialist B to serve as a research technician for the Castleman Disease Center at Penn (CDCP) and Fajgenbaum laboratory within the Division of Translational Medicine & Human Genetics. The CDCP was recently founded to elucidate the etiology, pathogenesis, diagnostic biomarkers, and life-saving therapeutics for Castleman disease (CD)—a group of poorly-understood and deadly inflammatory disorders—and related cytokine storm and inflammatory lymphoproliferative entities. Several projects homing in on novel insights into the etiology of and cell types, signaling pathways, and cytokines that drive CD pathogenesis as well as basic insights into human immunology are underway that need to be driven toward publication and dissemination. The position will involve small animal breeding and husbandry, human cell culture, nucleic acid and protein extraction, western blotting, ELISA, immunohistochemistry/immunofluorescence/in situ hybridization, flow cytometry, and analysis of associated data. This is a unique opportunity to join a highly motivated, patient-focused team that works closely with international collaborators to make and publish novel discoveries that will have a significant impact on patients who have diseases with major unmet medical need. This is also an excellent opportunity for professional growth and gaining scientific experiences on a collaborative and hardworking team. The Research Specialist B will report directly to the Director of Basic & Translational Research for the Center and will be expected to participate in lab meetings, discussions, manuscript development, follow laboratory protocols and processes, and assist with experiments of other lab members. The applicant must be well organized and is expected to maintain his/her own lab notebook. Additional responsibilities will include organizing/ordering materials and reagents for the lab, dealing with vendors, and sharing lab maintenance duties with other lab members. The successful candidate should have experience working in a laboratory, preferably one focused on human immunology that performed flow cytometry, omics techniques (WES, WGS, scRNAseq, proteomics, etc.), T and B cell repertoire profiling, functional immunological assays, studies using human tissue, and/or development of experimental systems.
Internal Number: 46563
About University of Pennsylvania
Penn has a long and proud tradition of intellectual rigor and pursuit of innovative knowledge, begun by Benjamin Franklin in 1740. That tradition lives today through the creativity, entrepreneurship, and engagement of our faculty, students, and staff. Academic life at Penn is unparalleled, with an undergraduate student body of 10,000 from every U.S. state and around the world. The entering class of 2015 is the most talented and diverse in Penn's history. Consistently ranked among the top 10 universities in the country, Penn welcomes an additional 10,000 students to our top-ranked graduate and professional schools.