The Castleman Disease Center at Penn (CDCP) was recently founded to elucidate the etiology, pathogenesis, diagnostic biomarkers, and life-saving therapeutics for Castleman disease (CD)—a group of poorly-understood and deadly inflammatory disorders—and related immunological disorders. The CDCP, in partnership with the Division of Translational Medicine & Human Genetics and the Fajgenbaum lab, is searching for a talented, experienced, and motivated Director of Research to oversee all ongoing CD research programs and take a leadership role to independently conceptualize, end-to-end design, and execute new basic and translational laboratory research projects on patient samples for the CDCP and Fajgenbaum lab. Reporting directly to the PI/Founding Director of the CDCP, the Director of Research will recruit, train, supervise, and mentor laboratory personnel, graduate students, and fellows to execute studies as well as oversee experiments, protocols, and processes performed by members of the CDCP and Fajgenbaum Lab. The Director of Research will work closely with major internal (PI, data coordinators, biostatisticians, IRB) and external (federal funding bodies, pharmaceutical companies, on- and off-campus investigators, European Medicines Agency, CROs, subcontractors, patient advocacy groups, partnering academic institutions, and key opinion leaders in CD) stakeholders to manage partnerships and ensure completion of project milestones and all reporting requirements. The Director of Research will lead interpretation of results and development of progress reports, grant applications, and manuscripts in peer-reviewed journals. Several projects homing in on novel insights into the etiology of and cell types, signaling pathways, and cytokines that drive idiopathic multicentric Castleman disease (iMCD) pathogenesis as well as basic insights into human immunology are underway that need to be driven toward publication and dissemination. These projects include investigation of the first novel therapeutic target (mammalian Target of Rapamycin) discovered in iMCD in 25 years (using flow cytometry, phospho-flow, and immunohistochemistry/immunofluorescence), which is funded through the first R01 awarded for iMCD research, whole exome sequencing of lymph node and constitutional DNA to search for pathological variants, single-cell transcriptional and T/B cell repertoire profiling of peripheral blood mononuclear cells, serum proteomics and pathogen discovery, and investigation of stromal cells and their chemokines in iMCD and human immunology. A significant number of publications are anticipated from these projects. Several already funded projects are also waiting for the Director of Research to be designed and initiated, such as correlative biomarker analyses for an upcoming clinical trial of a novel treatment identified by the Fajgenbaum Lab. This is a unique opportunity to join a highly motivated, patient-focused team that works closely with international collaborators to make and publish novel discoveries that will have a significant impact on patients who have diseases with major unmet medical need. This is also an excellent opportunity for a motivated scientist to grow his/her leadership experience and build a top notch translational research laboratory. The successful candidate should have an advanced understanding of human immunology and direct experience or familiarity with high-dimensional flow cytometry, cutting-edge sequencing/omics techniques (WES, WGS, scRNAseq, proteomics, etc.), T and B cell repertoire profiling, functional immunological assays, studies using human tissue, and development of experimental systems.
* Conceptualize, design and execute basic and translational laboratory research projects to generate data that can lead to biological insights. * Perform and/or oversee the performance of high-dimensional flow cytometry, sequencing, tissue-based assays, and other studies. * Recruit, train, supervise, and mentor laboratory personnel, graduate students, fellows, and scientific collaborators * Lead the data management, advanced analytics, interpretation, presentation, and manuscript writing/development for peer-reviewed publication for laboratory studies led by the CDCP and Fajgenbaum Lab * Oversee processes and protocols utilized in the laboratory and ensure that they are optimal.
Internal Number: 44470
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